2026-08-28
Viruses
Русский Proof-of-Concept Study for the Efficacy of Dispirotripiperazine PDSTP in a Mouse Model of Herpes Simplex Herpetic Encephalitis
K. Pomeshikova,O. Riabova,N. Monakhova,I. Leneva,G. Sanna,V. Makarov
Viruses. 2026-08-28
articles and reviews
Scientific publications
A bibliographic stream of laboratory papers, reviews, journal records, and attached materials.
2026-08-26
European Journal of Medicinal Chemistry
Design and anti-rhinovirus activity of novel derivatives based on the pleconaril core
A. Egorova,O. Riabova,E. Kazakova,S. de Jonghe,D. Jochmans,J. Neyts,M. Schmidtke,M. Cogoni,V. Palmas,M. Khrenova,G. Sanna,V. Makarov
European Journal of Medicinal Chemistry. 2026-08-26
2026-08-19
Studies in Natural Products Chemistry
Полусинтетический алкалоид виндебурнол: синтез и его влияние на центральную нервную систему
L. Borets,Y. Zorkina,O. Abramova,V. Ushakova,E. Zubkov,V. Makarov
Studies in Natural Products Chemistry. 2026-08-19
2026-08-15
Journal of Electroanalytical Chemistry
Photoelectrocatalytic oxidation of levofloxacin on titanium dioxide nanotubes in a 0.9% NaCl solution
V. Grinberg,V. Emets,V. Makarov,O. Riabova,A. Averin,N. Mayorova
Journal of Electroanalytical Chemistry. 2026-08-15
2026-07-22
Neuroscience and Biobehavioral Reviews
Ultrasound model of depression in rodents: a comprehensive analysis of validity, pathogenic mechanisms, and potential for translation to humans
A. Avdaseva,V. Ushakova,O. Abramova,Y. Zorkina,E. Zubkov,V. Makarov,V. Chekhonin,A. Morozova
Neuroscience and Biobehavioral Reviews. 2026-07-22
2026-06-09
Microbiology and Molecular Biology Reviews
Effective Influenza Treatment: A Comprehensive Review of Challenges and Advances
K. Pomeshikova,A. Poromov,M. Schmidtke,V. Makarov
Microbiology and Molecular Biology Reviews. 2026-06-09
2026-05-25
ACS Infection Diseases
The efficacy, structure-activity relationship, and mode of action studies of a new generation of acridine/acridone-based antimalarials
S. Maluf,G. Mendes,I. Moura,G. de Souza,T. Valdes,V. Bonatto,G. Oliveir,A. Oliveir,M. Gazarini,A. Puhl,N. Monakhova,A. Lepioshkin,V. Makarov,T. Lane,R. Raman,G. Campolina,C. Barbosa,A. Ferreira,C. Teles,D. Pereira,R. Barros,E. Benavente,S. Ekins,R. Guido
ACS Infection Diseases. 2026-05-25
2026-04-27
Communication Biology
Cytometric proteome profiling of GFP-tagged yeast for characterizing novel antifungals
E. Ghazy,V. Bidiuk,F. Ryabov,O. Mitkevich,O. Riabova,Y. Stanishevskiy,I. Levshin,L. Alexandrova,M. Jasko,D. Makarov,A. Zhgun,D. Avdanina,A. Ermolyuk,V. Kushnirov,A. Egorova,M. Agaphonov,A. Alexandrov
Communication Biology. 2026-04-27
2026-04-17
CNS & Neurological Disorders - Drug Targets
Vindeburnol induces neuroprotection in rat traumatic brain injury via adrenergic receptor antagonism
M. Ivanov,L. Borets,E. Yakupova,O. Riabova,A. Yurin,D. Silachev,V. Makarov
CNS & Neurological Disorders - Drug Targets. 2026-04-17
2026-04-06
ACS Omega
Enhanced Antiviral Activity of Novel Umifenovir Derivatives Against SARS-CoV-2: Insights from an International Collaborative Study
M. Mottin,C. Jurisch,S. Silva Mendonca,D. Seanego,P. Ramos,C. Freitas,M. Mattos,N. Fintelman-Rodrigues,C. Sacramento,F. Guivel-Benhassine,T. Bruel,L. Krugmann,A. Puhl,F. Urbina,T. Lane,E. Merten,K. Pearce,A. Lepioshkin,A. Poromov,N. Monakhova,O. Schwartz,K. Chibale,T. Souza,S. Ekins,V. Makarov,R. Gessner,C. Andrade
ACS Omega. 2026-04-06
2026-03-17
The EMBO Journal
Structural basis for EtfD-mediated coupling of β-oxidation and the respiratory chain in mycobacteria
G. Courbon,V. Makarov,S. Cole,D. Schnapinger,S. Ehrt,J. Rubinstein
The EMBO Journal. 2026-03-17
2026-01-21
Journal of Cultural Heritage
Biodeterioration Aspects of the 16th Century Icon “Deesis Tier of Thirteen Figures” by the Fungus Iodophanus sp. STG-150: a Range of Materials for Biodegradation and Selection of Target Antiseptics
D. Avdanina,O. Vorobyova,A. Ermolyuk,N. Simonenko,I. Volkov,L. Alexandrova,M. Jasko,V. Makarov,M. Khomutov,E. Khurs,A. Khomutov,O. Riabova,E. Troyan,M. Shitov,A. Zhgun
Journal of Cultural Heritage. 2026-01-21
2025-12-20
Journal of Solid State Electrochemistry
Photoelectrocatalytic degradation of molecular forms of non-steroidal anti-inflammatory drugs on TiO2 nanotubes in a 0.9% NaCl solution.
V. Emets,V. Grinberg,V. Makarov,A. Tsedilin,A. Averin,A. Shiryaev
Journal of Solid State Electrochemistry. 2025-12-20
2025-12-04
ACS Pharmacology & Translational Science
Comprehensive preclinical study of the procognitive effects, safety, and pharmacokinetics of vindeburnol
L. Borets,T. Azhikina,E. Zubkov,A. Tsedilin,O. Bychenko,A. Grigorov,Y. Zorkina,O. Riabova,O. Abramova,V. Ushakova,Y. Skvortsova,V. Makarov
ACS Pharmacology & Translational Science. 2025-12-04
2025-11-26
Drug Discovery Today
Impact on the virulence of Mycobacterium tuberculosis and non-tuberculous mycobacteria: focus on the development of anti-infective drugs
L. Chiarelli,A. Lepioshkin,M. Pasca,V. Makarov
Drug Discovery Today. 2025-11-26
2025-11-11
Бюллетень Экспериментальной Биологии и Медицины
Исследование противотуберкулезного препарата макозинона (PBTZ169) на кишечную микробиоту и иммунитет у инбредных мышей
B. Nikonenko,S. Kayukova,I. Bocharova,A. Donnikov,T. Azhikina,D. Dianov,V. Makarov
Бюллетень Экспериментальной Биологии и Медицины. 2025-11-11
2025-11-06
Chemical Biology & Drug Design
Protein kinase inhibitors: synthesis and molecular repurposing in three-dimensional cancer models
V. Lobanov,N. Rossomakhina,E. Kazakova,V. Zherdeva,V. Makarov
Chemical Biology & Drug Design. 2025-11-06
2025-07-24
Biomedicine & Pharmacotherapy
The formation of a ternary complex involving viral capsid protein 1 and two capsid-binding inhibitors explains the synergistic interactions observed in studies of combinations against rhinoviruses
M. Richter,M. Khrenova,O. Riabova,V. Makarov,M. Schmidtke
Biomedicine & Pharmacotherapy. 2025-07-24
2025-04-30
ACS Infectious Diseases
Cryo-EM structure of HIV-1 reverse transcriptase with N-phenyl-1-(phenylsulfonyl)-1H-1,2,4-triazol-3-amine: a novel non-nucleoside HIV-1 inhibitor
M. Young,T. Lane,R. Raman,J. Nelson,O. Riabova,E. Kazakova,N. Monakhova,A. Tsedilin,S. Rees,D. Quinnell,V. Makarov,G. Chang,S. Ekins
ACS Infectious Diseases. 2025-04-30
2025-03-20
ACS Infectious Diseases
The Mycobacterium tuberculosis sulfatase/dioxygenase Rv3406 is capable of inactivating the compound RCB18350.
D. Recchia,G. Stelitano,A. Egorova,G. Biffignandi,K. Savková,R. Kafkova,S. Huszár,A. Cerrato,R. Slayden,J. Cummings,N. Whittel,A. Bauman,G. Robertson,L. Rank,F. Urbina,T. Lane,S. Ekins,O. Riabova,E. Kazakova,K. Mikusova,D. Sassera,G. Degiacomi,L. Chiarelli,V. Makarov,M. Pasca
ACS Infectious Diseases. 2025-03-20
2025-03-10
Frontiers in Microbiology
Efficacy of the dispirotripiperazine PDSTP in SARS-CoV-2 infection models in Syrian golden hamsters
G. Sanna,O. Riabova,E. Kazakova,A. Lepioshkin,N. Monakhova,A. Marongiu,G. Franci,A. Manzin,V. Makarov
Frontiers in Microbiology. 2025-03-10
2025-02-20
Springer Nature Link
New heteroleptic palladium complexes with amino acid and bornane ligands: synthesis and antibacterial activity
Ya. Gur'eva,O. Zalevskaya,V. Makarov,A. Kutchin
Springer Nature Link. 2025-02-20
2025-02-18
Инфекционные болезни
Umifenovir (Arbidol) and acute rotavirus gastroenteritis: antiviral activity, mechanism of action, and a review and meta-analysis of clinical studies.
I. Leneva,A. Poromov,E. Fayzuloev,A. Gracheva,D. Usenko,K. Ermolenko,N. Pshenichnaya,S. Orlova,V. Makarov
Инфекционные болезни. 2025-02-18
2025-01-17
Microorganisms
Исследования in vivo и in vitro, измерение противовирусной эффективности двойных комбинаций против инфекции вирусом Коксаки Б.
A. Stoyanova,S. Galabov,V. Makarov,A. Galabov
Microorganisms. 2025-01-17
2024-12-11
ACS Chemical Neuroscience
Discovery of Dual Targeting GSK-3β/HIV-1 Reverse Transcriptase Inhibitors as Neuroprotective Antiviral Agents
T. Jones,R. Raman,A. Puhl,T. Lane,O. Riabova,E. Kazakova,N. Monakhova,V. Makarov,S. Ekins
ACS Chemical Neuroscience. 2024-12-11
2024-11-27
Antimicrobial Agents and Chemotherapy
Real-time evaluation of macozinone activity against Mycobacterium tuberculosis through bacterial nanomotion analysis
A. Vocat,A. Luraschi-Eggemann,C. Antoni,G. Cathomen,D. Cichocka,G. Greub,O. Riabova,V. Makarov,O. Opota,A. Mendoza,S. Cole,A. Sturm
Antimicrobial Agents and Chemotherapy. 2024-11-27
2024-09-28
Communications Biology
Nitric oxide induces the distinct invisibility phenotype of Mycobacterium tuberculosis
B. Gap-Gaupool,S. Glenn,E. Milburn,O. Turapov,M. Crosatti,J. Hincks,B. Stewart,J. Bacon,S. Kendall,M. Voskuil,O. Riabova,N. Monakhova,J. Green,S. Waddell,V. Makarov,G. Mukamolova
Communications Biology. 2024-09-28
2024-09-15
European Journal of Medicinal Chemistry
Vindeburnol: A natural product-inspired chemical tool for central nervous system drug design
A. Egorova,E. Zubkov,V. Makarov
European Journal of Medicinal Chemistry. 2024-09-15
2024-07-12
Antiviral Research
Dynamic features of virus protein 1 and substitutions in the 3-phenyl ring determine broad-spectrum activity of capsid-binding pyrazolopyrimidines
M. Richter,M. Khrenova,E. Kazakova,A. Egorova,O. Riabova,V. Makarov,M. Schmidtke
Antiviral Research. 2024-07-12
2024-06-20
European Journal of Medicinal Chemistry
Indole-core inhibitors of influenza A neuraminidase: iterative medicinal chemistry and molecular modeling
A. Tsedilin,M. Schmidtke,N. Monakhova,V. Makarov,I. Leneva,I. Falynskova,M. Khrenova,T. Lane,S. Ekins
European Journal of Medicinal Chemistry. 2024-06-20
2024-05-15
International Journal of Antimicrobial Agents
The novel drug candidate VOMG kills Mycobacterium abscessus and other pathogens by inhibiting cell division
G. Degiacomi,O. Riabova,N. Loré,V. Makarov,L. Chiarelli,L. Muñoz-Muñoz,D. Recchia D,G. Stelitano,U. Postiglione,F. Saliu,A. Griego,V. Scoffone,E. Kazakova,E. Scarpa,J. Ezquerra-Aznárez,A. Stamilla,S. Buroni,E. Tortoli,L. Rizzello,D. Sassera,S. Ramon-Garcia,D. Cirillo,M. Pasca
International Journal of Antimicrobial Agents. 2024-05-15
2024-04-26
Life Science Alliance
Modulating mycobacterial envelope Integrity for antibiotic synergy with benzothiazoles
E. Habjan,A. Lepioshkin,V. Charitou,A. Egorova,E. Kazakova,V. Ho,W. Bitter,V. Makarov,A. Speer
Life Science Alliance. 2024-04-26
2024-04-04
Microbes and Infection
Efficacy of macozinone in mice with genetically diverse susceptibility to tuberculosis infection
B. Nikonenko,N. Logunova,A. Egorova,M. Kapina,N. Sterzhanova,I. Bocharova,E. Kondratieva,O. Riabova,L. Semyonova,V. Makarov
Microbes and Infection. 2024-04-04
2024-02-16
Frontiers in Microbiology
Characterization of the dispirotripiperazine derivative PDSTP as antibiotic adjuvant and antivirulence compound against Pseudomonas aeruginosa
A. Bonacorsi,G. Trespidi,V. Scoffone ,S. Irudal,G. Barbieri,O. Riabova,N. Monakhova,V. Makarov,S. Buroni
Frontiers in Microbiology. 2024-02-16
2024-02-15
Journal of Pharmaceutical and Biomedical Analysis
Determination of alkaloid-inspired molecule vindeburnol in rabbit plasma by UPLC–HRMS and its application to pharmacokinetic studies and preliminary metabolite identification
A. Tsedilin,L. Borets,O. Riabova,E. Kazakova,V. Tafeenko,V. Makarov
Journal of Pharmaceutical and Biomedical Analysis. 2024-02-15
2024-01-24
Purinergic Signal
Machine learning-aided search for ligands of P2Y6 and other P2Y receptors
A. Puhl,S. Lewicki,Gao. Z,A. Pramanik,V. Makarov,S. Ekins,K. Jacobson
Purinergic Signal. 2024-01-24
2024-01-15
European Journal of Medicinal Chemistry
Benzothiozinone derivatives with anti-tubercular activity−further side chain investigation
X. Wu,W. Wang,G. Stelitano,O. Riabova,B. Wang,W. Niu,M. Cocorullo,R. Shi,L. Chiarelli,V. Makarov,Y. Lu ,C. Li,C. Qiao
European Journal of Medicinal Chemistry. 2024-01-15
2024-01-14
Antiviral Research
Molecular mechanism of rhinovirus escape from the pyrazolo[3,4-d]pyrimidine capsid-binding inhibitor OBR-5-340 via mutations distant from the binding pocket: derivatives that brake resistance
M. Richter,K. Döring,D. Blaas,O. Riabova,M. Khrenova,E. Kazakova,A. Egorova,V. Makarov,M. Schmidtke
Antiviral Research. 2024-01-14
2024-01-12
ACS Chemical Neuroscience
Antidepressant-like effect of the eburnamine-type molecule vindeburnol in rat and mouse models of ultrasound-induced depression
E. Zubkov,O. Riabova,Y. Zorkina,A. Egorova,V. Ushakova,A. Lepioshkin,E. Novoselova,O. Abramova ,A. Morozova,V. Chekhonin ,V. Makarov
ACS Chemical Neuroscience. 2024-01-12
2023-11-01
ACS Omega
1‑Sulfonyl-3-amino‑1H‑1,2,4-triazoles as yellow fever virus inhibitors: synthesis and structure-activity relationship
E. Kazakova,T. Lane,J. Jones,A. Puhl,O. Riabova,V. Makarov,S. Ekins
ACS Omega. 2023-11-01
2023-10-19
ACS Omega
Synthesis and evaluation of 9-aminoacridines with SARS-CoV-2 antiviral activity
T. Jones,N. Monakhova,F. Guivel-Benhassine,L. Lepioshkin,T. Bruel,T. Lane,O. Schwartz,A. Puhl,V. Makarov,S. Ekins
ACS Omega. 2023-10-19
2023-08-23
Journal of Medicinal Chemistry
Antiviral evaluation of dispirotripiperazines against hepatitis B virus
T. Jones,J. Tavis ,Q. Li ,O. Riabova,N. Monakhova,D. Bradley,T. Lane,V. Makarov,S. Ekins
Journal of Medicinal Chemistry. 2023-08-23
2023-07-12
Biomedicines
Side chain-modified benzothiazinone derivatives with anti-mycobacterial activity
D. Fan,B. Wang,G. Stelitano,K. Savková,O. Riabova,R. Shi ,X. Wu ,L. Chiarelli,K. Mikušová,V. Makarov,Y. Lu,Y. Hong,C. Qiao
Biomedicines. 2023-07-12
2023-07-03
ACS Omega
CanB, a druggable cellular target in Mycobacterium tuberculosis
G. Degiacomi,B. Gianibbi,D. Recchia,G. Stelitano,G. Truglio,P. Marra,A. Stamilla,V. Makarov,L. Chiarelli,F. Manetti,M. Pasca
ACS Omega. 2023-07-03
2023-06-21
RSC Advances
Pyrrolo[2,3-e]indazole as a novel chemotype for both influenza A virus and pneumococcal neuraminidase inhibitors
A. Egorova,M. Richter,M. Khrenova,E. Dietrich,A. Tsedilin,E. Kazakova,A. Lepioshkin,B. Jahn ,V. Chernyshev,M. Schmidtke,V. Makarov
RSC Advances. 2023-06-21
2023-05-02
Journal of Medicinal Chemistry
N-Phenyl-1-(phenylsulfonyl)-1H-1,2,4-triazol-3-amine as a new class of HIV-1 non-nucleoside reverse transcriptase inhibitor
T. Lane,V. Makarov,J. Nelson,R. Meeker,G. Sanna,O. Riabova,E. Kazakova,N. Monakhova,A. Tsedilin,F. Urbina,T. Jones,A. Suchy,S. Ekins
Journal of Medicinal Chemistry. 2023-05-02
2023-01-15
Journal of Chromatography B
Optimized LC-MS/MS quantification of tuberculosis drug candidate macozinone (PBTZ169), its dearomatized Meisenheimer Complex and other metabolites, in human plasma and urine
V. Desfontain,S. Guinchard,S. Marques,A. Vocat,F. Moulfi,F. Versace,J. Huser-Pittelou,A. Ivanyuk,C. Bardinet,V. Makarov,O. Ryabova,P. André,S. Prod'Hom,H. Chtioui,T. Buclin,S. Cole,L. Decosterd
Journal of Chromatography B. 2023-01-15
2022-12-12
Microbiology Spectrum
Antituberculosis macozinone extended-release tablets to enhance bioavailability: a pilot pharmacokinetic study in Beagle dogs
A. Koryakova,V. Shcherbakova,O. Riabova,Y. Kazaishvili,R. Bolgarin,V. Makarov
Microbiology Spectrum. 2022-12-12
2022-11-15
mSphere
A new benzothiazolthiazolidine derivative, 11726172, is active in vitro, in vivo, and against nonreplicating cells of Mycobacterium tuberculosis
E. Salina,U. Postiglione,L. Chiarelli,D. Recchia,M. Záhorszká ,A. Lepioshkin,N. Monakhova,A. Pál,A. Porta,G. Zanoni,J. Korduláková,E. Kazakova,D. Sassera,M. Pasca,V. Makarov,G. Degiacomi
mSphere. 2022-11-15
2022-11-08
Antibiotics
Bactericidal and anti-biofilm activity of the FtsZ inhibitor C109 against Acinetobacter baumannii
V. Scoffone,S. Irudal,A. Alshaar,A. Piazza,G. Trespidi,G. Barbieri,V. Makarov,R. Migliavacca,E. De Rossi,S. Buroni
Antibiotics. 2022-11-08
2022-11-08
International Journal of Molecular Sciences
New drugs and novel cellular targets against tuberculosis
G. Degiacomi,V. Makarov,M. Pasca,L. Chiarelli
International Journal of Molecular Sciences. 2022-11-08
2022-11-01
Bioorganic & Medicinal Chemistry
Multiple approaches to repurposing drugs for neuroblastoma
L. Rank,A. Puhl,T. Havener,E. Anderson,D. Foil,K. Zorn,N. Monakhova,O. Riabova,A. Hickey,V. Makarov,S. Ekins
Bioorganic & Medicinal Chemistry. 2022-11-01
2022-10-13
Antiviral Research
Broad-spectrum antiviral diazadispiroalkane core molecules block attachment and cell-to-cell spread of herpesviruses
A. Dohme,M. Knoblauch,A. Egorova,V. Makarov,E. Bogner
Antiviral Research. 2022-10-13
2022-09-06
Herald of the Russian Academy of Sciences
PDSTP is the first drug in class to treat coronavirus infection
V. Makarov,V. Popov
Herald of the Russian Academy of Sciences. 2022-09-06
2022-08-24
Frontiers in Cellular and Infection Microbiology
Dimethyl fumarate eliminates differentially culturable Mycobacterium tuberculosis in an intranasal murine model of tuberculosis
S. Glenn,O. Turapov ,V. Makarov,D. Kell,G. Mukamolova
Frontiers in Cellular and Infection Microbiology. 2022-08-24
2022-07-26
ChemMedChem
Thieno[2,3-d]pyrimidine-core compounds show activity against clinically relevant gram-positive bacteria
O. Riabova,A. Egorova,A. Lepioshkin,Y. Li,K. Voigt,F. Kloss,V. Makarov
ChemMedChem. 2022-07-26
2022-06-22
Antiviral Research
A proof-of-concept study for the efficacy of dispirotripiperazine PDSTP in a rabbit model of herpes simplex epithelial keratitis
L. Alimbarova,A. Egorova,O. Riabova,N. Monakhova,V. Makarov
Antiviral Research. 2022-06-22
2022-05-24
ACS Infectious Diseases
Pyronaridine protects against SARS-CoV-2 infection in mouse
A. Puhl,G. Gomes,S. Damasceno,A. Godoy,G. Noske,A. Nakamura,V. Gawriljuk,R. Fernandes,N. Monakhova,O. Riabova,T. Lane,V. Makarov,F. Veras,S. Batah,A. Fabro,G. Oliva,F. Cunha,J. Alves-Filh,T. Cunha,S. Ekins
ACS Infectious Diseases. 2022-05-24
2022-03-21
RSC Advances
Copper(II) complexes with terpene derivatives of ethylenediamine: synthesis, and antibacterial, antifungal and antioxidant activity
Y. Gur'eva,O. Zalevskaya,O. Shevchenko,P. Slepukhin,V. Makarov,A. Kuchin
RSC Advances. 2022-03-21
2022-01-12
Tuberculosis
Mycobacterium abscessus drug discovery using machine learning
A. Schmalstig,K. Zorn,S. Murcia,A. Robinson,S. Savina,E. Komarova,V. Makarov,M. Braunstein,S. Ekins
Tuberculosis. 2022-01-12
2021-12-21
Molecular Pharmaceutics
Machine learning models for Mycobacterium tuberculosis in vitro activity: prediction and target visualization`
T. Lane,F. Urbina,L. Rank,J. Gerlach,O. Riabova,A. Lepioshkin,E. Kazakova,A. Vocat,V. Tkachenko,S. Cole,V. Makarov,S. Ekins
Molecular Pharmaceutics. 2021-12-21
2021-12-10
International Journal of Molecular Sciences
Targeting non-replicating Mycobacterium tuberculosis and latent infection: alternatives and perspectives (mini-review)
A. Egorova,E. Salina,V. Makarov
International Journal of Molecular Sciences. 2021-12-10
2021-07-21
Journal of Chemical Information and Modeling
Development of machine learning models and the discovery of a new antiviral compound against yellow fever virus
V. Gawriljuk,D. Foil,A. Puhl,K. Zorn,T. Lane,O. Riabova,V. Makarov,A. Godoy,G. Oliva,S. Ekins
Journal of Chemical Information and Modeling. 2021-07-21
2021-07-13
Pathogens
Antistaphylococcal activity of the FtsZ inhibitor C109
G. Trespidi,V. Scoffone,G. Barbieri,F. Marchesini,A. Abualsha'ar,T. Coenye,F. Ungaro,V. Makarov,R. Migliavacca,E. De Ross,S. Buroni
Pathogens. 2021-07-13
2021-04-07
ACS Medicinal Chemistry Letters
Discovery of 5-Nitro-6-thiocyanatopyrimidines as Inhibitors of Cryptococcus neoformans and Cryptococcus gattii
M. Donlin,T. Lane,O. Riabova,A. Lepioshkin,E. Xu,J. Lin,V. Makarov,S. Ekins
ACS Medicinal Chemistry Letters. 2021-04-07
2021-03-18
Antimicrobial Agents and Chemotherapy
Diazadispiroalkane derivatives are new viral entry inhibitors
R. Adfeldt,J. Schmitz,B. Kropff,M. Thomas,N. Monakhova,J. Hölper,B. Klupp,T. Mettenleiter,V. Makarov,E. Bogner
Antimicrobial Agents and Chemotherapy. 2021-03-18
2021-03-12
Viruses
Small molecules — prospective novel HCMV inhibitors
E. Bogner,A. Egorova,V. Makarov
Viruses. 2021-03-12
2021-03-01
Medicinal Research Reviews
Pipeline of anti-Mycobacterium abscessus small molecules: Repurposable drugs and promising novel chemical entities
A. Egorova,M. Jackson,V. Gavrilyuk,V. Makarov
Medicinal Research Reviews. 2021-03-01
2021-02-27
Drug Dicovery Today
Nitric oxide-releasing compounds for the treatment of lung infections
L. Chiarelli,G. Degiacomi,A. Egorova,V. Makarov,M. Pasca
Drug Dicovery Today. 2021-02-27
2021-02-05
European Journal of Medicinal Chemistry
Dispirotripiperazine-core compounds, their biological activity with a focus on broad antiviral property, and perspectives in drug design (mini-review)
A. Egorova,E. Bogner,E. Novoselova,K. Zorn,S. Ekins,V. Makarov
European Journal of Medicinal Chemistry. 2021-02-05
2020-12-22
ACS Infectious Diseases
Design and synthesis of pyrano[3,2-b]indolones showing antimycobacterial activity
N. Monakhova,J. Korduláková,A. Vocat,A. Egorova,A. Lepioshkin,E. Salina,J. Nosek,E. Repková,J. Zemanová,H. Jurdáková,R. Górová,J. Roh,G. Degiacomi,J. Sammartino,M. Pasca,S. Cole,K. Mikušová,V. Makarov
ACS Infectious Diseases. 2020-12-22
2020-09-15
ACS Infectious Diseases 2020
6,11-Dioxobenzo[f]pyrido[1,2-a]indoles kill Mycobacterium tuberculosis by targeting iron-sulfur protein Rv0338c (IspQ), a putative redox sensor
R. Székely,M. Rengifo-Gonzale,V. Singh,O. Riabova,A. Benjak,J. Piton,M. Cimino,E. Kornobis,V. Mizrahi,K. Johnsson,G. Manina,V. Makarov,S. Cole
ACS Infectious Diseases 2020. 2020-09-15
2020-04-26
Russian Chemical Bulletin
WIN compounds: on the way to efficient antipicornaviral agent. A historical survey
A. Egorova,V. Makarov
Russian Chemical Bulletin. 2020-04-26
2020-04-07
Journal of Medicinal Chemistry
Molecule property analyses of active compounds for Mycobacterium tuberculosis
V. Makarov,E. Salina,R. Reynolds,P. Kyaw Zin,S. Ekins
Journal of Medicinal Chemistry. 2020-04-07
2020-04-07
Frontiers in Microbiology
Chemical, metabolic, and cellular characterization of a FtsZ inhibitor effective against Burkholderia cenocepacia
L. Chiarelli,V. Scoffone,G. Trespidi,G. Barbieri,O. Riabova,N. Monakhova,A. Porta,G. Manina,G. Riccardi,V. Makarov,S. Buroni
Frontiers in Microbiology. 2020-04-07
2020-03-26
Applied Sciences
Development of macozinone for TB treatment: an update
V. Makarov,K. Mikušová
Applied Sciences. 2020-03-26
2020-03-16
Molecules
The evolution of pleconaril: modified O-alkyl linker analogs have biological activity towards Coxsackievirus B3 Nancy
A. Volobueva,A. Egorova,A. Galochkina,S. Ekins,V. Zarubaev,V. Makarov
Molecules. 2020-03-16
2020-03-15
European Journal of Medicinal Chemistry
The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens
S. Buroni,V. Makarov,V. Scoffone,G. Trespidi,G. Riccardi,L. Chiarelli
European Journal of Medicinal Chemistry. 2020-03-15
2020-02-25
Frontiers in Microbiology
Rv0579 is involved in the resistance to the TP053 antitubercular prodrug
G. Mori,B. Orena,L. Chiarelli,G. Degiacomi,O. Riabova,J. Sammartino,V. Makarov,G. Riccardi,M. Pasca
Frontiers in Microbiology. 2020-02-25
2020-02-15
European Journal of Medicinal Chemistry
Novel pleconaril derivatives: Influence of substituents in the isoxazole and phenyl rings on the antiviral activity against enteroviruses
A. Egorova,E. Kazakova,B. Jahn,S. Ekins,V. Makarov,M. Schmidtke
European Journal of Medicinal Chemistry. 2020-02-15
2020-01-23
PLoS Pathogens
New 2-ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis
A. Lupien,C. Foo,S. Savina,A. Vocat,J. Piton,N. Monakhova,A. Benjak,D. Lamprecht,A. Steyn,K. Pethe,V. Makarov,S. Cole
PLoS Pathogens. 2020-01-23
2020-01-20
Nanomedicine
PEGylated mucus-penetrating nanocrystals for lung delivery of a new FtsZ inhibitor against Burkholderia cenocepacia infection
G. Costabile,R. Provenzano,A. Azzalin,V. Scoffone,L. Chiarelli,V. Rondelli,I. Grillo,T. Zinn,A. Lepioshkin,S. Savina,A. Miro,F. Quaglia,V. Makarov,T. Coenye,P. Brocca,G. Riccardi,S. Buroni,F. Ungaro
Nanomedicine. 2020-01-20
2019-12-04
Pharmaceutical Chemistry Journal
Specific antiviral activity of pyrimidinedispirotripiperazinium alone and in combination with acyclovir on a herpes-simplex-virus model
E. Novoselova,O. Ryabova,I. Leneva,V. Makarov
Pharmaceutical Chemistry Journal. 2019-12-04
2019-11-22
International Journal of Molecular Sciences
Mycobacterium abscessus, an emerging and worrisome pathogen among cystic fibrosis patients
G. Degiacomi,J. Sammartino,L. Chiarelli,O. Riabova,V. Makarov,M. Pasca
International Journal of Molecular Sciences. 2019-11-22
2019-11-15
ACS Infectious Diseases
New insights into the mechanism of action of the thienopyrimidine antitubercular prodrug TP053
l. Chiarelli,E. Salina,G. Mori,T. Azhikina,O. Riabova,A. Lepioshkin,A. Grigorov,M. Forbak,J. Madacki,B. Orena,M. Manfredi,F. Gosetti,A. Buzzi,G. Degiacomi,J. Sammartino,E. Marengo,J. Korduláková,G. Riccardi,K. Mikušová,V. Makarov,M. Pasca
ACS Infectious Diseases. 2019-11-15
2019-09-21
Antibiotics
The effect of 2-thiocyanatopyridine derivative 11026103 on Burkholderia cenocepacia: resistance mechanisms and systemic impact
J. Nunvar,A. Hogan,S. Buroni,S. Savina,V. Makarov,S. Cardona,P. Drevinek
Antibiotics. 2019-09-21
2019-09-15
European Journal of Medicinal Chemistry
Back to the future: Advances in development of broad-spectrum capsid-binding inhibitors of enteroviruses
A. Egorova,S. Ekins,M. Schmidtke,V. Makarov
European Journal of Medicinal Chemistry. 2019-09-15
2019-08-28
Proceedings of the National Academy of Sciences
Cryo-EM structure of pleconaril-resistant rhinovirus-B5 complexed to the antiviral OBR-5-340 reveals unexpected binding site
J. Wald,M. Pasin,M. Richter,C. Walther,N. Mathai,J. Kirchmair,V. Makarov,N. Goessweiner-Moh,T. Marlovits,I. Zanella,A. Real-Hohn,N. Verdaguer,D. Blaas,M. Schmidtke
Proceedings of the National Academy of Sciences. 2019-08-28
2019-05-31
PLoS One
Development and validation of a multiplex UHPLC-MS/MS method for the determination of the investigational antibiotic against multi-resistant tuberculosis macozinone (PBTZ169) and five active metabolites in human plasma
D. Spaggiari,V. Desfontaine,S. Cruchon,S. Guinchard,A. Vocat,E. Blattes,J. Pitteloud,L. Ciullini,C. Bardinet,A. Ivanyuk,V. Makarov,O. Ryabova,T. Buclin,S. Cole,L. Decosterd
PLoS One. 2019-05-31
2019-05-14
Drug Discovery Today
New targets for HIV drug discovery
A. Puhl,A. Garzino Demo,V. Makarov,S. Ekins
Drug Discovery Today. 2019-05-14
2019-02-19
Molecular Pharmaceutics
Multiple machine learning comparisons of HIV cell-based and reverse transcriptase data sets
K. Zorn,T. Lane,D. Russo,A. Clark,V. Makarov,S. Ekins
Molecular Pharmaceutics. 2019-02-19
2018-11-26
Antimicrobial Agents and Chemotherapy
Competitive fitness of essential gene knockdowns reveals a broad-spectrum antibacterial inhibitor of the cell division protein FtsZ
E. Salina,L. Chiarelli,M. Paska,V. Makarov
Antimicrobial Agents and Chemotherapy. 2018-11-26
2018-11-23
Chemical Biology & Drug Design
A rapid method for estimation of the efficacy of potential antimicrobials in humans and animals by agar diffusion assay
E. Salina,S. Ekins,V. Makarov
Chemical Biology & Drug Design. 2018-11-23
2018-11-15
International Journal of Mycobacteriology
How to kill dormant Mycobacterium tuberculosis
A. Kaprelyants,E. Salina,V. Makarov
International Journal of Mycobacteriology. 2018-11-15
2018-10-24
Antimicrobial Agents and Chemotherapy
Optimized background regimen for treatment of active tuberculosis with the next-generation benzothiazinone macozinone (PBTZ169)
A. Lupien,A. Vocat,C. Foo,E. Blattes,J. Gillon,V. Makarov,S. Cole
Antimicrobial Agents and Chemotherapy. 2018-10-24
2018-10-05
ACS Chemical Biology
Fluorescent benzothiazinone analogues efficiently and selectively label DprE1 in mycobacteria and actinobacteria
R. Sommer,J. Neres,J. Piton,N. Dhar,A. van der Sar,R. Mukherjee,T. Laroche,P. Dyson,J. McKinney,W. Bitter,V. Makarov,S. Cole
ACS Chemical Biology. 2018-10-05
2018-09-24
Antimicrobial Agents and Chemotherapy
Structure-based drug design and characterization of sulfonyl-piperazine benzothiazinone inhibitors of DprE1 from Mycobacterium tuberculosis
J. Piton ,A. Vocat,A. Lupien,C. Foo,O. Riabova,V. Makarov,S. Cole
Antimicrobial Agents and Chemotherapy. 2018-09-24
2018-07-31
Frontiers in Pharmacology
Investigating the mechanism of action of diketopiperazines inhibitors of the Burkholderia cenocepacia quorum sensing synthase CepI: a site-directed mutagenesis study
S. Buroni,V. Scoffone,M. Fumagalli,V. Makarov,M. Cagnone,G. Trespidi,E. De Rossi,F. Forneris,G. Riccardi,L. Chiarelli
Frontiers in Pharmacology. 2018-07-31
2018-06-18
Metallomics
Copper-related toxicity in replicating and dormant Mycobacterium tuberculosis caused by 1-hydroxy-5-R-pyridine-2(1H)-thiones
E. Salina,S. Huszár,J. Zemanová,J. Keruchenko,O. Riabova,E. Kazakova,A. Grigorov,T. Azhikina,A. Kaprelyants,K. Mikušová,V. Makarov
Metallomics. 2018-06-18
2018-02-16
Scientific Reports
A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK
L. Chiarelli,G. Mori,B. Orena,M. Esposito,T. Lane,A. de Jesus Lopes Ribeiro,G. Degiacomi,J. Zemanová,S. Szádocka,S. Huszár,Z. Palčeková,M. Manfredi,F. Gosetti,E. Kazakova,V. Makarov,E. Marengo,K. Mikusova
Scientific Reports. 2018-02-16