articles and reviews

Scientific publications

A bibliographic stream of laboratory papers, reviews, journal records, and attached materials.

Novel Antiviral Drug Candidate Acts by Binding to the Hemagglutinin Stem

N. Monakhova,V. Lobanov,A. Poromov,A. Lepioshkin,O. Riabova,E. Kazakova,K. Pomeshikova,I. Leneva,A. Volobueva,I. Esaulkova,I. Lavrentieva,A. Shtro,A. Galochkina,A. Komissarov,M. Khrenova,V. Makarov

Antiviral Research. 2026-11-01

Open record

2026-10-13

BMC Microbiology

The dispirotripiperazine compound PDSTP impairs Pseudomonas aeruginosa and Burkholderia cenocepacia adhesion to lung epithelial cells through a novel mechanism of action

G. Trespidi,S. Costa,A. Bonacorsi,M. Spatafora,M. Peviani,O. Riabova,M. Pasca,V. Makarov,S. Buroni

BMC Microbiology. 2026-10-13

Open record

2026-10-12

Journal of Medicinal Chemistry

Antivirulence benzothiophenes inhibit intracellular Mycobacterium tuberculosis by targeting the sensor histidine kinase MprB

V. Lobanov,A. Lupien,A. Vocat,R. Singh,A. Lepioshkin,N. Monakhova,O. Riabova,M. Khrenova,S. Cole,V. Makarov

Journal of Medicinal Chemistry. 2026-10-12

Open record

2026-10-08

Frontiers in Cellular and Infection Microbiology

Dimethyl Fumarate Derivatives as Potential Leads for Targeting Mycobacterium tuberculosis Persisters

A. Herbert,O. Turapov,F. Macdonald,I. Djaharuddin,M. Massi,D. Kell,V. Makarov,G. Mukamolova

Frontiers in Cellular and Infection Microbiology. 2026-10-08

Article file Open record

2026-10-07

EMBO Molecular Medicine

Human prostaglandin reductases dearomatize the potent antitubercular agent macozinone (PBTZ169) into a Hydride Meisenheimer Complex

L. Decosterd,M. Briki,C. Wagner,V. Desfontaine,O. Opota,S. Abou-Zite,B. Cena,S. Guinchard,F. Versace,E. Blattes,C. Bardinet,H. Chtioui,A. Nahimana,A. Bellotti,N. Dhar,R. Mishra,R. Sommer ,A. Lupien,M. Duchosal,B. Guery,G. Milano,O. Ryabova ,V. Makarov,T. Buclin,S. Cole,E. Choong

EMBO Molecular Medicine. 2026-10-07

Article file Open record

2026-08-28

Viruses

Русский Proof-of-Concept Study for the Efficacy of Dispirotripiperazine PDSTP in a Mouse Model of Herpes Simplex Herpetic Encephalitis

K. Pomeshikova,O. Riabova,N. Monakhova,I. Leneva,G. Sanna,V. Makarov

Viruses. 2026-08-28

Article file Open record

2026-08-26

European Journal of Medicinal Chemistry

Design and anti-rhinovirus activity of novel derivatives based on the pleconaril core

A. Egorova,O. Riabova,E. Kazakova,S. de Jonghe,D. Jochmans,J. Neyts,M. Schmidtke,M. Cogoni,V. Palmas,M. Khrenova,G. Sanna,V. Makarov

European Journal of Medicinal Chemistry. 2026-08-26

Open record

2026-08-19

Studies in Natural Products Chemistry

Полусинтетический алкалоид виндебурнол: синтез и его влияние на центральную нервную систему

L. Borets,Y. Zorkina,O. Abramova,V. Ushakova,E. Zubkov,V. Makarov

Studies in Natural Products Chemistry. 2026-08-19

Open record

2026-08-15

Journal of Electroanalytical Chemistry

Photoelectrocatalytic oxidation of levofloxacin on titanium dioxide nanotubes in a 0.9% NaCl solution

V. Grinberg,V. Emets,V. Makarov,O. Riabova,A. Averin,N. Mayorova

Journal of Electroanalytical Chemistry. 2026-08-15

Open record

2026-07-22

Neuroscience and Biobehavioral Reviews

Ultrasound model of depression in rodents: a comprehensive analysis of validity, pathogenic mechanisms, and potential for translation to humans

A. Avdaseva,V. Ushakova,O. Abramova,Y. Zorkina,E. Zubkov,V. Makarov,V. Chekhonin,A. Morozova

Neuroscience and Biobehavioral Reviews. 2026-07-22

Open record

2026-06-09

Microbiology and Molecular Biology Reviews

Effective Influenza Treatment: A Comprehensive Review of Challenges and Advances

K. Pomeshikova,A. Poromov,M. Schmidtke,V. Makarov

Microbiology and Molecular Biology Reviews. 2026-06-09

Open record

2026-05-25

ACS Infection Diseases

The efficacy, structure-activity relationship, and mode of action studies of a new generation of acridine/acridone-based antimalarials

S. Maluf,G. Mendes,I. Moura,G. de Souza,T. Valdes,V. Bonatto,G. Oliveir,A. Oliveir,M. Gazarini,A. Puhl,N. Monakhova,A. Lepioshkin,V. Makarov,T. Lane,R. Raman,G. Campolina,C. Barbosa,A. Ferreira,C. Teles,D. Pereira,R. Barros,E. Benavente,S. Ekins,R. Guido

ACS Infection Diseases. 2026-05-25

Article file Open record

2026-04-27

Communication Biology

Cytometric proteome profiling of GFP-tagged yeast for characterizing novel antifungals

E. Ghazy,V. Bidiuk,F. Ryabov,O. Mitkevich,O. Riabova,Y. Stanishevskiy,I. Levshin,L. Alexandrova,M. Jasko,D. Makarov,A. Zhgun,D. Avdanina,A. Ermolyuk,V. Kushnirov,A. Egorova,M. Agaphonov,A. Alexandrov

Communication Biology. 2026-04-27

Article file Open record

2026-04-17

CNS & Neurological Disorders - Drug Targets

Vindeburnol induces neuroprotection in rat traumatic brain injury via adrenergic receptor antagonism

M. Ivanov,L. Borets,E. Yakupova,O. Riabova,A. Yurin,D. Silachev,V. Makarov

CNS & Neurological Disorders - Drug Targets. 2026-04-17

Article file Open record

2026-04-06

ACS Omega

Enhanced Antiviral Activity of Novel Umifenovir Derivatives Against SARS-CoV-2: Insights from an International Collaborative Study

M. Mottin,C. Jurisch,S. Silva Mendonca,D. Seanego,P. Ramos,C. Freitas,M. Mattos,N. Fintelman-Rodrigues,C. Sacramento,F. Guivel-Benhassine,T. Bruel,L. Krugmann,A. Puhl,F. Urbina,T. Lane,E. Merten,K. Pearce,A. Lepioshkin,A. Poromov,N. Monakhova,O. Schwartz,K. Chibale,T. Souza,S. Ekins,V. Makarov,R. Gessner,C. Andrade

ACS Omega. 2026-04-06

Article file Open record

2026-03-17

The EMBO Journal

Structural basis for EtfD-mediated coupling of β-oxidation and the respiratory chain in mycobacteria

G. Courbon,V. Makarov,S. Cole,D. Schnapinger,S. Ehrt,J. Rubinstein

The EMBO Journal. 2026-03-17

Article file Open record

2026-01-21

Journal of Cultural Heritage

Biodeterioration Aspects of the 16th Century Icon “Deesis Tier of Thirteen Figures” by the Fungus Iodophanus sp. STG-150: a Range of Materials for Biodegradation and Selection of Target Antiseptics

D. Avdanina,O. Vorobyova,A. Ermolyuk,N. Simonenko,I. Volkov,L. Alexandrova,M. Jasko,V. Makarov,M. Khomutov,E. Khurs,A. Khomutov,O. Riabova,E. Troyan,M. Shitov,A. Zhgun

Journal of Cultural Heritage. 2026-01-21

Article file Open record

2025-12-20

Journal of Solid State Electrochemistry

Photoelectrocatalytic degradation of molecular forms of non-steroidal anti-inflammatory drugs on TiO2 nanotubes in a 0.9% NaCl solution.

V. Emets,V. Grinberg,V. Makarov,A. Tsedilin,A. Averin,A. Shiryaev

Journal of Solid State Electrochemistry. 2025-12-20

Open record

2025-12-04

ACS Pharmacology & Translational Science

Comprehensive preclinical study of the procognitive effects, safety, and pharmacokinetics of vindeburnol

L. Borets,T. Azhikina,E. Zubkov,A. Tsedilin,O. Bychenko,A. Grigorov,Y. Zorkina,O. Riabova,O. Abramova,V. Ushakova,Y. Skvortsova,V. Makarov

ACS Pharmacology & Translational Science. 2025-12-04

Open record

2025-11-26

Drug Discovery Today

Impact on the virulence of Mycobacterium tuberculosis and non-tuberculous mycobacteria: focus on the development of anti-infective drugs

L. Chiarelli,A. Lepioshkin,M. Pasca,V. Makarov

Drug Discovery Today. 2025-11-26

Article file Open record

2025-11-11

Бюллетень Экспериментальной Биологии и Медицины

Исследование противотуберкулезного препарата макозинона (PBTZ169) на кишечную микробиоту и иммунитет у инбредных мышей

B. Nikonenko,S. Kayukova,I. Bocharova,A. Donnikov,T. Azhikina,D. Dianov,V. Makarov

Бюллетень Экспериментальной Биологии и Медицины. 2025-11-11

Open record

2025-11-06

Chemical Biology & Drug Design

Protein kinase inhibitors: synthesis and molecular repurposing in three-dimensional cancer models

V. Lobanov,N. Rossomakhina,E. Kazakova,V. Zherdeva,V. Makarov

Chemical Biology & Drug Design. 2025-11-06

Open record

2025-07-24

Biomedicine & Pharmacotherapy

The formation of a ternary complex involving viral capsid protein 1 and two capsid-binding inhibitors explains the synergistic interactions observed in studies of combinations against rhinoviruses

M. Richter,M. Khrenova,O. Riabova,V. Makarov,M. Schmidtke

Biomedicine & Pharmacotherapy. 2025-07-24

Article file Open record

2025-04-30

ACS Infectious Diseases

Cryo-EM structure of HIV-1 reverse transcriptase with N-phenyl-1-(phenylsulfonyl)-1H-1,2,4-triazol-3-amine: a novel non-nucleoside HIV-1 inhibitor

M. Young,T. Lane,R. Raman,J. Nelson,O. Riabova,E. Kazakova,N. Monakhova,A. Tsedilin,S. Rees,D. Quinnell,V. Makarov,G. Chang,S. Ekins

ACS Infectious Diseases. 2025-04-30

Open record

2025-03-20

ACS Infectious Diseases

The Mycobacterium tuberculosis sulfatase/dioxygenase Rv3406 is capable of inactivating the compound RCB18350.

D. Recchia,G. Stelitano,A. Egorova,G. Biffignandi,K. Savková,R. Kafkova,S. Huszár,A. Cerrato,R. Slayden,J. Cummings,N. Whittel,A. Bauman,G. Robertson,L. Rank,F. Urbina,T. Lane,S. Ekins,O. Riabova,E. Kazakova,K. Mikusova,D. Sassera,G. Degiacomi,L. Chiarelli,V. Makarov,M. Pasca

ACS Infectious Diseases. 2025-03-20

Article file Open record

2025-03-10

Frontiers in Microbiology

Efficacy of the dispirotripiperazine PDSTP in SARS-CoV-2 infection models in Syrian golden hamsters

G. Sanna,O. Riabova,E. Kazakova,A. Lepioshkin,N. Monakhova,A. Marongiu,G. Franci,A. Manzin,V. Makarov

Frontiers in Microbiology. 2025-03-10

Article file Open record

2025-02-20

Springer Nature Link

New heteroleptic palladium complexes with amino acid and bornane ligands: synthesis and antibacterial activity

Ya. Gur'eva,O. Zalevskaya,V. Makarov,A. Kutchin

Springer Nature Link. 2025-02-20

Open record

2025-02-18

Инфекционные болезни

Umifenovir (Arbidol) and acute rotavirus gastroenteritis: antiviral activity, mechanism of action, and a review and meta-analysis of clinical studies.

I. Leneva,A. Poromov,E. Fayzuloev,A. Gracheva,D. Usenko,K. Ermolenko,N. Pshenichnaya,S. Orlova,V. Makarov

Инфекционные болезни. 2025-02-18

Article file Open record

2025-01-17

Microorganisms

Исследования in vivo и in vitro, измерение противовирусной эффективности двойных комбинаций против инфекции вирусом Коксаки Б.

A. Stoyanova,S. Galabov,V. Makarov,A. Galabov

Microorganisms. 2025-01-17

Article file Open record

2024-12-11

ACS Chemical Neuroscience

Discovery of Dual Targeting GSK-3β/HIV-1 Reverse Transcriptase Inhibitors as Neuroprotective Antiviral Agents

T. Jones,R. Raman,A. Puhl,T. Lane,O. Riabova,E. Kazakova,N. Monakhova,V. Makarov,S. Ekins

ACS Chemical Neuroscience. 2024-12-11

Open record

2024-11-27

Antimicrobial Agents and Chemotherapy

Real-time evaluation of macozinone activity against Mycobacterium tuberculosis through bacterial nanomotion analysis

A. Vocat,A. Luraschi-Eggemann,C. Antoni,G. Cathomen,D. Cichocka,G. Greub,O. Riabova,V. Makarov,O. Opota,A. Mendoza,S. Cole,A. Sturm

Antimicrobial Agents and Chemotherapy. 2024-11-27

Open record

2024-09-28

Communications Biology

Nitric oxide induces the distinct invisibility phenotype of Mycobacterium tuberculosis

B. Gap-Gaupool,S. Glenn,E. Milburn,O. Turapov,M. Crosatti,J. Hincks,B. Stewart,J. Bacon,S. Kendall,M. Voskuil,O. Riabova,N. Monakhova,J. Green,S. Waddell,V. Makarov,G. Mukamolova

Communications Biology. 2024-09-28

Article file Open record

2024-09-15

European Journal of Medicinal Chemistry

Vindeburnol: A natural product-inspired chemical tool for central nervous system drug design

A. Egorova,E. Zubkov,V. Makarov

European Journal of Medicinal Chemistry. 2024-09-15

Open record

2024-07-12

Antiviral Research

Dynamic features of virus protein 1 and substitutions in the 3-phenyl ring determine broad-spectrum activity of capsid-binding pyrazolopyrimidines

M. Richter,M. Khrenova,E. Kazakova,A. Egorova,O. Riabova,V. Makarov,M. Schmidtke

Antiviral Research. 2024-07-12

Article file Open record

2024-06-20

European Journal of Medicinal Chemistry

Indole-core inhibitors of influenza A neuraminidase: iterative medicinal chemistry and molecular modeling

A. Tsedilin,M. Schmidtke,N. Monakhova,V. Makarov,I. Leneva,I. Falynskova,M. Khrenova,T. Lane,S. Ekins

European Journal of Medicinal Chemistry. 2024-06-20

Article file Open record

2024-05-15

International Journal of Antimicrobial Agents

The novel drug candidate VOMG kills Mycobacterium abscessus and other pathogens by inhibiting cell division

G. Degiacomi,O. Riabova,N. Loré,V. Makarov,L. Chiarelli,L. Muñoz-Muñoz,D. Recchia D,G. Stelitano,U. Postiglione,F. Saliu,A. Griego,V. Scoffone,E. Kazakova,E. Scarpa,J. Ezquerra-Aznárez,A. Stamilla,S. Buroni,E. Tortoli,L. Rizzello,D. Sassera,S. Ramon-Garcia,D. Cirillo,M. Pasca

International Journal of Antimicrobial Agents. 2024-05-15

Article file Open record

2024-04-26

Life Science Alliance

Modulating mycobacterial envelope Integrity for antibiotic synergy with benzothiazoles

E. Habjan,A. Lepioshkin,V. Charitou,A. Egorova,E. Kazakova,V. Ho,W. Bitter,V. Makarov,A. Speer

Life Science Alliance. 2024-04-26

Article file Open record

2024-04-04

Microbes and Infection

Efficacy of macozinone in mice with genetically diverse susceptibility to tuberculosis infection

B. Nikonenko,N. Logunova,A. Egorova,M. Kapina,N. Sterzhanova,I. Bocharova,E. Kondratieva,O. Riabova,L. Semyonova,V. Makarov

Microbes and Infection. 2024-04-04

Article file Open record

2024-02-16

Frontiers in Microbiology

Characterization of the dispirotripiperazine derivative PDSTP as antibiotic adjuvant and antivirulence compound against Pseudomonas aeruginosa

A. Bonacorsi,G. Trespidi,V. Scoffone ,S. Irudal,G. Barbieri,O. Riabova,N. Monakhova,V. Makarov,S. Buroni

Frontiers in Microbiology. 2024-02-16

Article file Open record

2024-02-15

Journal of Pharmaceutical and Biomedical Analysis

Determination of alkaloid-inspired molecule vindeburnol in rabbit plasma by UPLC–HRMS and its application to pharmacokinetic studies and preliminary metabolite identification

A. Tsedilin,L. Borets,O. Riabova,E. Kazakova,V. Tafeenko,V. Makarov

Journal of Pharmaceutical and Biomedical Analysis. 2024-02-15

Open record

2024-01-24

Purinergic Signal

Machine learning-aided search for ligands of P2Y6 and other P2Y receptors

A. Puhl,S. Lewicki,Gao. Z,A. Pramanik,V. Makarov,S. Ekins,K. Jacobson

Purinergic Signal. 2024-01-24

Article file Open record

2024-01-15

European Journal of Medicinal Chemistry

Benzothiozinone derivatives with anti-tubercular activity−further side chain investigation

X. Wu,W. Wang,G. Stelitano,O. Riabova,B. Wang,W. Niu,M. Cocorullo,R. Shi,L. Chiarelli,V. Makarov,Y. Lu ,C. Li,C. Qiao

European Journal of Medicinal Chemistry. 2024-01-15

Open record

2024-01-14

Antiviral Research

Molecular mechanism of rhinovirus escape from the pyrazolo[3,4-d]pyrimidine capsid-binding inhibitor OBR-5-340 via mutations distant from the binding pocket: derivatives that brake resistance

M. Richter,K. Döring,D. Blaas,O. Riabova,M. Khrenova,E. Kazakova,A. Egorova,V. Makarov,M. Schmidtke

Antiviral Research. 2024-01-14

Article file Open record

2024-01-12

ACS Chemical Neuroscience

Antidepressant-like effect of the eburnamine-type molecule vindeburnol in rat and mouse models of ultrasound-induced depression

E. Zubkov,O. Riabova,Y. Zorkina,A. Egorova,V. Ushakova,A. Lepioshkin,E. Novoselova,O. Abramova ,A. Morozova,V. Chekhonin ,V. Makarov

ACS Chemical Neuroscience. 2024-01-12

Article file Open record

2023-11-01

ACS Omega

1‑Sulfonyl-3-amino‑1H‑1,2,4-triazoles as yellow fever virus inhibitors: synthesis and structure-activity relationship

E. Kazakova,T. Lane,J. Jones,A. Puhl,O. Riabova,V. Makarov,S. Ekins

ACS Omega. 2023-11-01

Article file Open record

2023-10-19

ACS Omega

Synthesis and evaluation of 9-aminoacridines with SARS-CoV-2 antiviral activity

T. Jones,N. Monakhova,F. Guivel-Benhassine,L. Lepioshkin,T. Bruel,T. Lane,O. Schwartz,A. Puhl,V. Makarov,S. Ekins

ACS Omega. 2023-10-19

Article file Open record

2023-08-23

Journal of Medicinal Chemistry

Antiviral evaluation of dispirotripiperazines against hepatitis B virus

T. Jones,J. Tavis ,Q. Li ,O. Riabova,N. Monakhova,D. Bradley,T. Lane,V. Makarov,S. Ekins

Journal of Medicinal Chemistry. 2023-08-23

Open record

2023-07-12

Biomedicines

Side chain-modified benzothiazinone derivatives with anti-mycobacterial activity

D. Fan,B. Wang,G. Stelitano,K. Savková,O. Riabova,R. Shi ,X. Wu ,L. Chiarelli,K. Mikušová,V. Makarov,Y. Lu,Y. Hong,C. Qiao

Biomedicines. 2023-07-12

Article file Open record

2023-07-03

ACS Omega

CanB, a druggable cellular target in Mycobacterium tuberculosis

G. Degiacomi,B. Gianibbi,D. Recchia,G. Stelitano,G. Truglio,P. Marra,A. Stamilla,V. Makarov,L. Chiarelli,F. Manetti,M. Pasca

ACS Omega. 2023-07-03

Article file Open record

2023-06-21

RSC Advances

Pyrrolo[2,3-e]indazole as a novel chemotype for both influenza A virus and pneumococcal neuraminidase inhibitors

A. Egorova,M. Richter,M. Khrenova,E. Dietrich,A. Tsedilin,E. Kazakova,A. Lepioshkin,B. Jahn ,V. Chernyshev,M. Schmidtke,V. Makarov

RSC Advances. 2023-06-21

Article file Open record

2023-05-02

Journal of Medicinal Chemistry

N-Phenyl-1-(phenylsulfonyl)-1H-1,2,4-triazol-3-amine as a new class of HIV-1 non-nucleoside reverse transcriptase inhibitor

T. Lane,V. Makarov,J. Nelson,R. Meeker,G. Sanna,O. Riabova,E. Kazakova,N. Monakhova,A. Tsedilin,F. Urbina,T. Jones,A. Suchy,S. Ekins

Journal of Medicinal Chemistry. 2023-05-02

Open record

2023-01-15

Journal of Chromatography B

Optimized LC-MS/MS quantification of tuberculosis drug candidate macozinone (PBTZ169), its dearomatized Meisenheimer Complex and other metabolites, in human plasma and urine

V. Desfontain,S. Guinchard,S. Marques,A. Vocat,F. Moulfi,F. Versace,J. Huser-Pittelou,A. Ivanyuk,C. Bardinet,V. Makarov,O. Ryabova,P. André,S. Prod'Hom,H. Chtioui,T. Buclin,S. Cole,L. Decosterd

Journal of Chromatography B. 2023-01-15

Article file Open record

2022-12-12

Microbiology Spectrum

Antituberculosis macozinone extended-release tablets to enhance bioavailability: a pilot pharmacokinetic study in Beagle dogs

A. Koryakova,V. Shcherbakova,O. Riabova,Y. Kazaishvili,R. Bolgarin,V. Makarov

Microbiology Spectrum. 2022-12-12

Open record

2022-11-25

Microorganisms

Mycobacterium tuberculosis dormancy: how to fight a hidden danger

E. Salina,V. Makarov

Microorganisms. 2022-11-25

Article file Open record

2022-11-15

mSphere

A new benzothiazolthiazolidine derivative, 11726172, is active in vitro, in vivo, and against nonreplicating cells of Mycobacterium tuberculosis

E. Salina,U. Postiglione,L. Chiarelli,D. Recchia,M. Záhorszká ,A. Lepioshkin,N. Monakhova,A. Pál,A. Porta,G. Zanoni,J. Korduláková,E. Kazakova,D. Sassera,M. Pasca,V. Makarov,G. Degiacomi

mSphere. 2022-11-15

Open record

2022-11-08

Antibiotics

Bactericidal and anti-biofilm activity of the FtsZ inhibitor C109 against Acinetobacter baumannii

V. Scoffone,S. Irudal,A. Alshaar,A. Piazza,G. Trespidi,G. Barbieri,V. Makarov,R. Migliavacca,E. De Rossi,S. Buroni

Antibiotics. 2022-11-08

Article file Open record

2022-11-08

International Journal of Molecular Sciences

New drugs and novel cellular targets against tuberculosis

G. Degiacomi,V. Makarov,M. Pasca,L. Chiarelli

International Journal of Molecular Sciences. 2022-11-08

Article file Open record

2022-11-01

Bioorganic & Medicinal Chemistry

Multiple approaches to repurposing drugs for neuroblastoma

L. Rank,A. Puhl,T. Havener,E. Anderson,D. Foil,K. Zorn,N. Monakhova,O. Riabova,A. Hickey,V. Makarov,S. Ekins

Bioorganic & Medicinal Chemistry. 2022-11-01

Open record

2022-10-13

Antiviral Research

Broad-spectrum antiviral diazadispiroalkane core molecules block attachment and cell-to-cell spread of herpesviruses

A. Dohme,M. Knoblauch,A. Egorova,V. Makarov,E. Bogner

Antiviral Research. 2022-10-13

Open record

2022-09-06

Herald of the Russian Academy of Sciences

PDSTP is the first drug in class to treat coronavirus infection

V. Makarov,V. Popov

Herald of the Russian Academy of Sciences. 2022-09-06

Article file Open record

2022-08-24

Frontiers in Cellular and Infection Microbiology

Dimethyl fumarate eliminates differentially culturable Mycobacterium tuberculosis in an intranasal murine model of tuberculosis

S. Glenn,O. Turapov ,V. Makarov,D. Kell,G. Mukamolova

Frontiers in Cellular and Infection Microbiology. 2022-08-24

Article file Open record

2022-07-26

ChemMedChem

Thieno[2,3-d]pyrimidine-core compounds show activity against clinically relevant gram-positive bacteria

O. Riabova,A. Egorova,A. Lepioshkin,Y. Li,K. Voigt,F. Kloss,V. Makarov

ChemMedChem. 2022-07-26

Open record

2022-06-22

Antiviral Research

A proof-of-concept study for the efficacy of dispirotripiperazine PDSTP in a rabbit model of herpes simplex epithelial keratitis

L. Alimbarova,A. Egorova,O. Riabova,N. Monakhova,V. Makarov

Antiviral Research. 2022-06-22

Open record

2022-05-24

ACS Infectious Diseases

Pyronaridine protects against SARS-CoV-2 infection in mouse

A. Puhl,G. Gomes,S. Damasceno,A. Godoy,G. Noske,A. Nakamura,V. Gawriljuk,R. Fernandes,N. Monakhova,O. Riabova,T. Lane,V. Makarov,F. Veras,S. Batah,A. Fabro,G. Oliva,F. Cunha,J. Alves-Filh,T. Cunha,S. Ekins

ACS Infectious Diseases. 2022-05-24

Open record

2022-03-21

RSC Advances

Copper(II) complexes with terpene derivatives of ethylenediamine: synthesis, and antibacterial, antifungal and antioxidant activity

Y. Gur'eva,O. Zalevskaya,O. Shevchenko,P. Slepukhin,V. Makarov,A. Kuchin

RSC Advances. 2022-03-21

Open record

2022-01-12

Tuberculosis

Mycobacterium abscessus drug discovery using machine learning

A. Schmalstig,K. Zorn,S. Murcia,A. Robinson,S. Savina,E. Komarova,V. Makarov,M. Braunstein,S. Ekins

Tuberculosis. 2022-01-12

Open record

2021-12-21

Molecular Pharmaceutics

Machine learning models for Mycobacterium tuberculosis in vitro activity: prediction and target visualization`

T. Lane,F. Urbina,L. Rank,J. Gerlach,O. Riabova,A. Lepioshkin,E. Kazakova,A. Vocat,V. Tkachenko,S. Cole,V. Makarov,S. Ekins

Molecular Pharmaceutics. 2021-12-21

Open record

2021-12-10

International Journal of Molecular Sciences

Targeting non-replicating Mycobacterium tuberculosis and latent infection: alternatives and perspectives (mini-review)

A. Egorova,E. Salina,V. Makarov

International Journal of Molecular Sciences. 2021-12-10

Article file Open record

2021-07-21

Journal of Chemical Information and Modeling

Development of machine learning models and the discovery of a new antiviral compound against yellow fever virus

V. Gawriljuk,D. Foil,A. Puhl,K. Zorn,T. Lane,O. Riabova,V. Makarov,A. Godoy,G. Oliva,S. Ekins

Journal of Chemical Information and Modeling. 2021-07-21

Open record

2021-07-13

Pathogens

Antistaphylococcal activity of the FtsZ inhibitor C109

G. Trespidi,V. Scoffone,G. Barbieri,F. Marchesini,A. Abualsha'ar,T. Coenye,F. Ungaro,V. Makarov,R. Migliavacca,E. De Ross,S. Buroni

Pathogens. 2021-07-13

Article file Open record

2021-04-07

ACS Medicinal Chemistry Letters

Discovery of 5-Nitro-6-thiocyanatopyrimidines as Inhibitors of Cryptococcus neoformans and Cryptococcus gattii

M. Donlin,T. Lane,O. Riabova,A. Lepioshkin,E. Xu,J. Lin,V. Makarov,S. Ekins

ACS Medicinal Chemistry Letters. 2021-04-07

Open record

2021-03-18

Antimicrobial Agents and Chemotherapy

Diazadispiroalkane derivatives are new viral entry inhibitors

R. Adfeldt,J. Schmitz,B. Kropff,M. Thomas,N. Monakhova,J. Hölper,B. Klupp,T. Mettenleiter,V. Makarov,E. Bogner

Antimicrobial Agents and Chemotherapy. 2021-03-18

Open record

2021-03-12

Viruses

Small molecules — prospective novel HCMV inhibitors

E. Bogner,A. Egorova,V. Makarov

Viruses. 2021-03-12

Article file Open record

2021-03-01

Medicinal Research Reviews

Pipeline of anti-Mycobacterium abscessus small molecules: Repurposable drugs and promising novel chemical entities

A. Egorova,M. Jackson,V. Gavrilyuk,V. Makarov

Medicinal Research Reviews. 2021-03-01

Open record

2021-02-27

Drug Dicovery Today

Nitric oxide-releasing compounds for the treatment of lung infections

L. Chiarelli,G. Degiacomi,A. Egorova,V. Makarov,M. Pasca

Drug Dicovery Today. 2021-02-27

Open record

2021-02-05

European Journal of Medicinal Chemistry

Dispirotripiperazine-core compounds, their biological activity with a focus on broad antiviral property, and perspectives in drug design (mini-review)

A. Egorova,E. Bogner,E. Novoselova,K. Zorn,S. Ekins,V. Makarov

European Journal of Medicinal Chemistry. 2021-02-05

Article file Open record

2020-12-22

ACS Infectious Diseases

Design and synthesis of pyrano[3,2-b]indolones showing antimycobacterial activity

N. Monakhova,J. Korduláková,A. Vocat,A. Egorova,A. Lepioshkin,E. Salina,J. Nosek,E. Repková,J. Zemanová,H. Jurdáková,R. Górová,J. Roh,G. Degiacomi,J. Sammartino,M. Pasca,S. Cole,K. Mikušová,V. Makarov

ACS Infectious Diseases. 2020-12-22

Open record

2020-09-15

ACS Infectious Diseases 2020

6,11-Dioxobenzo[f]pyrido[1,2-a]indoles kill Mycobacterium tuberculosis by targeting iron-sulfur protein Rv0338c (IspQ), a putative redox sensor

R. Székely,M. Rengifo-Gonzale,V. Singh,O. Riabova,A. Benjak,J. Piton,M. Cimino,E. Kornobis,V. Mizrahi,K. Johnsson,G. Manina,V. Makarov,S. Cole

ACS Infectious Diseases 2020. 2020-09-15

Article file Open record

2020-04-26

Russian Chemical Bulletin

WIN compounds: on the way to efficient antipicornaviral agent. A historical survey

A. Egorova,V. Makarov

Russian Chemical Bulletin. 2020-04-26

Open record

2020-04-07

Journal of Medicinal Chemistry

Molecule property analyses of active compounds for Mycobacterium tuberculosis

V. Makarov,E. Salina,R. Reynolds,P. Kyaw Zin,S. Ekins

Journal of Medicinal Chemistry. 2020-04-07

Open record

2020-04-07

Frontiers in Microbiology

Chemical, metabolic, and cellular characterization of a FtsZ inhibitor effective against Burkholderia cenocepacia

L. Chiarelli,V. Scoffone,G. Trespidi,G. Barbieri,O. Riabova,N. Monakhova,A. Porta,G. Manina,G. Riccardi,V. Makarov,S. Buroni

Frontiers in Microbiology. 2020-04-07

Article file Open record

2020-03-26

Applied Sciences

Development of macozinone for TB treatment: an update

V. Makarov,K. Mikušová

Applied Sciences. 2020-03-26

Article file Open record

2020-03-16

Molecules

The evolution of pleconaril: modified O-alkyl linker analogs have biological activity towards Coxsackievirus B3 Nancy

A. Volobueva,A. Egorova,A. Galochkina,S. Ekins,V. Zarubaev,V. Makarov

Molecules. 2020-03-16

Article file Open record

2020-03-15

European Journal of Medicinal Chemistry

The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens

S. Buroni,V. Makarov,V. Scoffone,G. Trespidi,G. Riccardi,L. Chiarelli

European Journal of Medicinal Chemistry. 2020-03-15

Open record

2020-02-25

Frontiers in Microbiology

Rv0579 is involved in the resistance to the TP053 antitubercular prodrug

G. Mori,B. Orena,L. Chiarelli,G. Degiacomi,O. Riabova,J. Sammartino,V. Makarov,G. Riccardi,M. Pasca

Frontiers in Microbiology. 2020-02-25

Article file Open record

2020-02-15

European Journal of Medicinal Chemistry

Novel pleconaril derivatives: Influence of substituents in the isoxazole and phenyl rings on the antiviral activity against enteroviruses

A. Egorova,E. Kazakova,B. Jahn,S. Ekins,V. Makarov,M. Schmidtke

European Journal of Medicinal Chemistry. 2020-02-15

Open record

2020-01-23

PLoS Pathogens

New 2-ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis

A. Lupien,C. Foo,S. Savina,A. Vocat,J. Piton,N. Monakhova,A. Benjak,D. Lamprecht,A. Steyn,K. Pethe,V. Makarov,S. Cole

PLoS Pathogens. 2020-01-23

Article file Open record

2020-01-20

Nanomedicine

PEGylated mucus-penetrating nanocrystals for lung delivery of a new FtsZ inhibitor against Burkholderia cenocepacia infection

G. Costabile,R. Provenzano,A. Azzalin,V. Scoffone,L. Chiarelli,V. Rondelli,I. Grillo,T. Zinn,A. Lepioshkin,S. Savina,A. Miro,F. Quaglia,V. Makarov,T. Coenye,P. Brocca,G. Riccardi,S. Buroni,F. Ungaro

Nanomedicine. 2020-01-20

Article file Open record

2019-12-04

Pharmaceutical Chemistry Journal

Specific antiviral activity of pyrimidinedispirotripiperazinium alone and in combination with acyclovir on a herpes-simplex-virus model

E. Novoselova,O. Ryabova,I. Leneva,V. Makarov

Pharmaceutical Chemistry Journal. 2019-12-04

Open record

2019-11-22

International Journal of Molecular Sciences

Mycobacterium abscessus, an emerging and worrisome pathogen among cystic fibrosis patients

G. Degiacomi,J. Sammartino,L. Chiarelli,O. Riabova,V. Makarov,M. Pasca

International Journal of Molecular Sciences. 2019-11-22

Article file Open record

2019-11-15

ACS Infectious Diseases

New insights into the mechanism of action of the thienopyrimidine antitubercular prodrug TP053

l. Chiarelli,E. Salina,G. Mori,T. Azhikina,O. Riabova,A. Lepioshkin,A. Grigorov,M. Forbak,J. Madacki,B. Orena,M. Manfredi,F. Gosetti,A. Buzzi,G. Degiacomi,J. Sammartino,E. Marengo,J. Korduláková,G. Riccardi,K. Mikušová,V. Makarov,M. Pasca

ACS Infectious Diseases. 2019-11-15

Open record

2019-09-21

Antibiotics

The effect of 2-thiocyanatopyridine derivative 11026103 on Burkholderia cenocepacia: resistance mechanisms and systemic impact

J. Nunvar,A. Hogan,S. Buroni,S. Savina,V. Makarov,S. Cardona,P. Drevinek

Antibiotics. 2019-09-21

Article file Open record

2019-09-15

European Journal of Medicinal Chemistry

Back to the future: Advances in development of broad-spectrum capsid-binding inhibitors of enteroviruses

A. Egorova,S. Ekins,M. Schmidtke,V. Makarov

European Journal of Medicinal Chemistry. 2019-09-15

Open record

2019-08-28

Proceedings of the National Academy of Sciences

Cryo-EM structure of pleconaril-resistant rhinovirus-B5 complexed to the antiviral OBR-5-340 reveals unexpected binding site

J. Wald,M. Pasin,M. Richter,C. Walther,N. Mathai,J. Kirchmair,V. Makarov,N. Goessweiner-Moh,T. Marlovits,I. Zanella,A. Real-Hohn,N. Verdaguer,D. Blaas,M. Schmidtke

Proceedings of the National Academy of Sciences. 2019-08-28

Article file Open record

2019-05-31

PLoS One

Development and validation of a multiplex UHPLC-MS/MS method for the determination of the investigational antibiotic against multi-resistant tuberculosis macozinone (PBTZ169) and five active metabolites in human plasma

D. Spaggiari,V. Desfontaine,S. Cruchon,S. Guinchard,A. Vocat,E. Blattes,J. Pitteloud,L. Ciullini,C. Bardinet,A. Ivanyuk,V. Makarov,O. Ryabova,T. Buclin,S. Cole,L. Decosterd

PLoS One. 2019-05-31

Article file Open record

2019-05-14

Drug Discovery Today

New targets for HIV drug discovery

A. Puhl,A. Garzino Demo,V. Makarov,S. Ekins

Drug Discovery Today. 2019-05-14

Open record

2019-02-19

Molecular Pharmaceutics

Multiple machine learning comparisons of HIV cell-based and reverse transcriptase data sets

K. Zorn,T. Lane,D. Russo,A. Clark,V. Makarov,S. Ekins

Molecular Pharmaceutics. 2019-02-19

Open record

2018-11-26

Antimicrobial Agents and Chemotherapy

Competitive fitness of essential gene knockdowns reveals a broad-spectrum antibacterial inhibitor of the cell division protein FtsZ

E. Salina,L. Chiarelli,M. Paska,V. Makarov

Antimicrobial Agents and Chemotherapy. 2018-11-26

Open record

2018-11-23

Chemical Biology & Drug Design

A rapid method for estimation of the efficacy of potential antimicrobials in humans and animals by agar diffusion assay

E. Salina,S. Ekins,V. Makarov

Chemical Biology & Drug Design. 2018-11-23

Open record

2018-11-15

International Journal of Mycobacteriology

How to kill dormant Mycobacterium tuberculosis

A. Kaprelyants,E. Salina,V. Makarov

International Journal of Mycobacteriology. 2018-11-15

Article file Open record

2018-10-24

Antimicrobial Agents and Chemotherapy

Optimized background regimen for treatment of active tuberculosis with the next-generation benzothiazinone macozinone (PBTZ169)

A. Lupien,A. Vocat,C. Foo,E. Blattes,J. Gillon,V. Makarov,S. Cole

Antimicrobial Agents and Chemotherapy. 2018-10-24

Open record

2018-10-05

ACS Chemical Biology

Fluorescent benzothiazinone analogues efficiently and selectively label DprE1 in mycobacteria and actinobacteria

R. Sommer,J. Neres,J. Piton,N. Dhar,A. van der Sar,R. Mukherjee,T. Laroche,P. Dyson,J. McKinney,W. Bitter,V. Makarov,S. Cole

ACS Chemical Biology. 2018-10-05

Open record

2018-09-24

Antimicrobial Agents and Chemotherapy

Structure-based drug design and characterization of sulfonyl-piperazine benzothiazinone inhibitors of DprE1 from Mycobacterium tuberculosis

J. Piton ,A. Vocat,A. Lupien,C. Foo,O. Riabova,V. Makarov,S. Cole

Antimicrobial Agents and Chemotherapy. 2018-09-24

Open record

2018-07-31

Frontiers in Pharmacology

Investigating the mechanism of action of diketopiperazines inhibitors of the Burkholderia cenocepacia quorum sensing synthase CepI: a site-directed mutagenesis study

S. Buroni,V. Scoffone,M. Fumagalli,V. Makarov,M. Cagnone,G. Trespidi,E. De Rossi,F. Forneris,G. Riccardi,L. Chiarelli

Frontiers in Pharmacology. 2018-07-31

Article file Open record

2018-06-18

Metallomics

Copper-related toxicity in replicating and dormant Mycobacterium tuberculosis caused by 1-hydroxy-5-R-pyridine-2(1H)-thiones

E. Salina,S. Huszár,J. Zemanová,J. Keruchenko,O. Riabova,E. Kazakova,A. Grigorov,T. Azhikina,A. Kaprelyants,K. Mikušová,V. Makarov

Metallomics. 2018-06-18

Open record

2018-02-16

Scientific Reports

A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK

L. Chiarelli,G. Mori,B. Orena,M. Esposito,T. Lane,A. de Jesus Lopes Ribeiro,G. Degiacomi,J. Zemanová,S. Szádocka,S. Huszár,Z. Palčeková,M. Manfredi,F. Gosetti,E. Kazakova,V. Makarov,E. Marengo,K. Mikusova

Scientific Reports. 2018-02-16

Article file Open record

Scientific publications

Novel Antiviral Drug Candidate Acts by Binding to the Hemagglutinin Stem

The dispirotripiperazine compound PDSTP impairs Pseudomonas aeruginosa and Burkholderia cenocepacia adhesion to lung epithelial cells through a novel mechanism of action

Antivirulence benzothiophenes inhibit intracellular Mycobacterium tuberculosis by targeting the sensor histidine kinase MprB

Dimethyl Fumarate Derivatives as Potential Leads for Targeting Mycobacterium tuberculosis Persisters

Human prostaglandin reductases dearomatize the potent antitubercular agent macozinone (PBTZ169) into a Hydride Meisenheimer Complex

Русский Proof-of-Concept Study for the Efficacy of Dispirotripiperazine PDSTP in a Mouse Model of Herpes Simplex Herpetic Encephalitis

Design and anti-rhinovirus activity of novel derivatives based on the pleconaril core

Полусинтетический алкалоид виндебурнол: синтез и его влияние на центральную нервную систему

Photoelectrocatalytic oxidation of levofloxacin on titanium dioxide nanotubes in a 0.9% NaCl solution

Ultrasound model of depression in rodents: a comprehensive analysis of validity, pathogenic mechanisms, and potential for translation to humans

Effective Influenza Treatment: A Comprehensive Review of Challenges and Advances

The efficacy, structure-activity relationship, and mode of action studies of a new generation of acridine/acridone-based antimalarials

Cytometric proteome profiling of GFP-tagged yeast for characterizing novel antifungals

Vindeburnol induces neuroprotection in rat traumatic brain injury via adrenergic receptor antagonism

Enhanced Antiviral Activity of Novel Umifenovir Derivatives Against SARS-CoV-2: Insights from an International Collaborative Study

Structural basis for EtfD-mediated coupling of β-oxidation and the respiratory chain in mycobacteria

Biodeterioration Aspects of the 16th Century Icon “Deesis Tier of Thirteen Figures” by the Fungus Iodophanus sp. STG-150: a Range of Materials for Biodegradation and Selection of Target Antiseptics

Photoelectrocatalytic degradation of molecular forms of non-steroidal anti-inflammatory drugs on TiO2 nanotubes in a 0.9% NaCl solution.

Comprehensive preclinical study of the procognitive effects, safety, and pharmacokinetics of vindeburnol

Impact on the virulence of Mycobacterium tuberculosis and non-tuberculous mycobacteria: focus on the development of anti-infective drugs

Исследование противотуберкулезного препарата макозинона (PBTZ169) на кишечную микробиоту и иммунитет у инбредных мышей

Protein kinase inhibitors: synthesis and molecular repurposing in three-dimensional cancer models

The formation of a ternary complex involving viral capsid protein 1 and two capsid-binding inhibitors explains the synergistic interactions observed in studies of combinations against rhinoviruses

Cryo-EM structure of HIV-1 reverse transcriptase with N-phenyl-1-(phenylsulfonyl)-1H-1,2,4-triazol-3-amine: a novel non-nucleoside HIV-1 inhibitor

The Mycobacterium tuberculosis sulfatase/dioxygenase Rv3406 is capable of inactivating the compound RCB18350.

Efficacy of the dispirotripiperazine PDSTP in SARS-CoV-2 infection models in Syrian golden hamsters

New heteroleptic palladium complexes with amino acid and bornane ligands: synthesis and antibacterial activity

Umifenovir (Arbidol) and acute rotavirus gastroenteritis: antiviral activity, mechanism of action, and a review and meta-analysis of clinical studies.

Исследования in vivo и in vitro, измерение противовирусной эффективности двойных комбинаций против инфекции вирусом Коксаки Б.

Discovery of Dual Targeting GSK-3β/HIV-1 Reverse Transcriptase Inhibitors as Neuroprotective Antiviral Agents

Real-time evaluation of macozinone activity against Mycobacterium tuberculosis through bacterial nanomotion analysis

Nitric oxide induces the distinct invisibility phenotype of Mycobacterium tuberculosis

Vindeburnol: A natural product-inspired chemical tool for central nervous system drug design

Dynamic features of virus protein 1 and substitutions in the 3-phenyl ring determine broad-spectrum activity of capsid-binding pyrazolopyrimidines

Indole-core inhibitors of influenza A neuraminidase: iterative medicinal chemistry and molecular modeling

The novel drug candidate VOMG kills Mycobacterium abscessus and other pathogens by inhibiting cell division

Modulating mycobacterial envelope Integrity for antibiotic synergy with benzothiazoles

Efficacy of macozinone in mice with genetically diverse susceptibility to tuberculosis infection

Characterization of the dispirotripiperazine derivative PDSTP as antibiotic adjuvant and antivirulence compound against Pseudomonas aeruginosa

Determination of alkaloid-inspired molecule vindeburnol in rabbit plasma by UPLC–HRMS and its application to pharmacokinetic studies and preliminary metabolite identification

Machine learning-aided search for ligands of P2Y6 and other P2Y receptors

Benzothiozinone derivatives with anti-tubercular activity−further side chain investigation

Molecular mechanism of rhinovirus escape from the pyrazolo[3,4-d]pyrimidine capsid-binding inhibitor OBR-5-340 via mutations distant from the binding pocket: derivatives that brake resistance

Antidepressant-like effect of the eburnamine-type molecule vindeburnol in rat and mouse models of ultrasound-induced depression

1‑Sulfonyl-3-amino‑1H‑1,2,4-triazoles as yellow fever virus inhibitors: synthesis and structure-activity relationship

Synthesis and evaluation of 9-aminoacridines with SARS-CoV-2 antiviral activity

Antiviral evaluation of dispirotripiperazines against hepatitis B virus

Side chain-modified benzothiazinone derivatives with anti-mycobacterial activity

CanB, a druggable cellular target in Mycobacterium tuberculosis

Pyrrolo[2,3-e]indazole as a novel chemotype for both influenza A virus and pneumococcal neuraminidase inhibitors

N-Phenyl-1-(phenylsulfonyl)-1H-1,2,4-triazol-3-amine as a new class of HIV-1 non-nucleoside reverse transcriptase inhibitor

Optimized LC-MS/MS quantification of tuberculosis drug candidate macozinone (PBTZ169), its dearomatized Meisenheimer Complex and other metabolites, in human plasma and urine

Antituberculosis macozinone extended-release tablets to enhance bioavailability: a pilot pharmacokinetic study in Beagle dogs

Mycobacterium tuberculosis dormancy: how to fight a hidden danger

A new benzothiazolthiazolidine derivative, 11726172, is active in vitro, in vivo, and against nonreplicat﻿ing cells of Mycobacterium tuberculosis

Bactericidal and anti-biofilm activity of the FtsZ inhibitor C109 against Acinetobacter baumannii

New drugs and novel cellular targets against tuberculosis

Multiple approaches to repurposing drugs for neuroblastoma

Broad-spectrum antiviral diazadispiroalkane core molecules block attachment and cell-to-cell spread of herpesviruses

PDSTP is the first drug in class to treat coronavirus infection

Dimethyl fumarate eliminates differentially culturable Mycobacterium tuberculosis in an intranasal murine model of tuberculosis

Thieno[2,3-d]pyrimidine-core compounds show activity against clinically relevant gram-positive bacteria

A proof-of-concept study for the efficacy of dispirotripiperazine PDSTP in a rabbit model of herpes simplex epithelial keratitis

Pyronaridine protects against SARS-CoV-2 infection in mouse

Copper(II) complexes with terpene derivatives of ethylenediamine: synthesis, and antibacterial, antifungal and antioxidant activity

Mycobacterium abscessus drug discovery using machine learning

Machine learning models for Mycobacterium tuberculosis in vitro activity: prediction and target visualization`

Targeting non-replicating Mycobacterium tuberculosis and latent infection: alternatives and perspectives (mini-review)

Development of machine learning models and the discovery of a new antiviral compound against yellow fever virus

Antistaphylococcal activity of the FtsZ inhibitor C109

Discovery of 5-Nitro-6-thiocyanatopyrimidines as Inhibitors of Cryptococcus neoformans and Cryptococcus gattii

Diazadispiroalkane derivatives are new viral entry inhibitors

Small molecules — prospective novel HCMV inhibitors

Pipeline of anti-Mycobacterium abscessus small molecules: Repurposable drugs and promising novel chemical entities

Nitric oxide-releasing compounds for the treatment of lung infections

Dispirotripiperazine-core compounds, their biological activity with a focus on broad antiviral property, and perspectives in drug design (mini-review)

Design and synthesis of pyrano[3,2-b]indolones showing antimycobacterial activity

6,11-Dioxobenzo[f]pyrido[1,2-a]indoles kill Mycobacterium tuberculosis by targeting iron-sulfur protein Rv0338c (IspQ), a putative redox sensor

WIN compounds: on the way to efficient antipicornaviral agent. A historical survey

A new benzothiazolthiazolidine derivative, 11726172, is active in vitro, in vivo, and against nonreplicating cells of Mycobacterium tuberculosis