Research Center of Biotechnology RAS
Medicinal Chemistry Laboratory
A full-cycle research group: molecular design, organic synthesis, biological testing, and publication data analysis.
Directions
Research program
The work is organized around therapeutic questions where a chemical hypothesis is quickly tested through experiments and publication data.
archive
Latest publications
Antiviral Research
Novel Antiviral Drug Candidate Acts by Binding to the Hemagglutinin Stem
N. Monakhova,V. Lobanov,A. Poromov,A. Lepioshkin,O. Riabova,E. Kazakova,K. Pomeshikova,I. Leneva,A. Volobueva,I. Esaulkova,I. Lavrentieva,A. Shtro,A. Galochkina,A. Komissarov,M. Khrenova,V. Makarov
2026-11-01
BMC Microbiology
The dispirotripiperazine compound PDSTP impairs Pseudomonas aeruginosa and Burkholderia cenocepacia adhesion to lung epithelial cells through a novel mechanism of action
G. Trespidi,S. Costa,A. Bonacorsi,M. Spatafora,M. Peviani,O. Riabova,M. Pasca,V. Makarov,S. Buroni
2026-10-13
Journal of Medicinal Chemistry
Antivirulence benzothiophenes inhibit intracellular Mycobacterium tuberculosis by targeting the sensor histidine kinase MprB
V. Lobanov,A. Lupien,A. Vocat,R. Singh,A. Lepioshkin,N. Monakhova,O. Riabova,M. Khrenova,S. Cole,V. Makarov
2026-10-12
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Laboratory news
2026-11-03
Research assistant Kristina Pomeshchikova gave a presentation titled “PDSTP — Antiviral drug with a novel mechanism of action, efficacy and safety profile” at a student research competition held as part of the 3rd International Conference “Innovative Medicines: From Molecule to Patient,” and took FIRST PLACE. For this, you’ll need to create a single, comprehensive image—by combining two separate ones.
2026-10-23
A key paper has been published in the journal Antiviral Research (10.1016/j.antiviral.2026.106550) by laboratory staff, detailing the discovery and a series of preclinical studies of a new drug candidate for the treatment of influenza. The lead compound targets the influenza virus hemagglutinin, thereby blocking the virus’s ability to fuse with the host cell membrane.
2026-10-09