Расширяя горизонты
медицинской химии
для здоровья людей

Лаборатория медицинской химии в ФИЦ Биотехнологии РАН

Мы занимаемся ранней разработкой низкомолекулярных лекарств
и созданием молекул-зондов для изучения биологических процессов

Направления исследований

Исторически занимаясь разработкой молекул для борьбы с инфекциями, сейчас мы осваиваем новые направления

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ВИЧ

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Риновирус

Антибиотики

Резистентность к препаратам

Рак

Деменция

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Наши последние публикации

Characterization of the dispirotripiperazine derivative PDSTP as antibiotic adjuvant and antivirulence compound against Pseudomonas aeruginosa

Bonacorsi A, Trespidi G, Scoffone VC, Irudal S, Barbieri G, Riabova O, Monakhova N, Makarov V, Buroni S
Frontiers in Microbiology. 2024

Molecular mechanism of rhinovirus escape from the pyrazolo[3,4-d]pyrimidine capsid-binding inhibitor OBR-5-340 via mutations distant from the binding pocket: derivatives that brake resistance

Richter M, Döring K, Blaas D, Riabova O, Khrenova M, Kazakova E, Egorova A, Makarov V, Schmidtke M
Antiviral Research, 2024

Antidepressant-like effect of the eburnamine-type molecule vindeburnol in rat and mouse models of ultrasound-induced depression

Zubkov E, Riabova O, Zorkina Y, Egorova A, Ushakova V, Lepioshkin A, Novoselova E, Abramova O, Morozova A, Chekhonin VP, Makarov V
ACS Chemical Neuroscience, 2024

Determination of alkaloid-inspired molecule vindeburnol in rabbit plasma by UPLC–HRMS and its application to pharmacokinetic studies and preliminary metabolite identification

Tsedilin A, Borets L, Riabova O, Kazakova E, Tafeenko V, Makarov V.
Journal of Pharmaceutical and Biomedical Analysis, 2024

Benzothiozinone derivatives with anti-tubercular activity−further side chain investigation

Wu X, Wang W, Stelitano G, Riabova O, Wang B, Niu W, Cocorullo M, Shi R, Chiarelli LR, Makarov V, Lu Y, Li C, Qiao C.
European Journal of Medicinal Chemistry, 2024

N-Phenyl-1-(phenylsulfonyl)-1H-1,2,4-triazol-3-amine as a new class of HIV-1 non-nucleoside reverse transcriptase inhibitor

Lane T, Makarov V, Nelson JAE, Meeker RB, Sanna G, Riabova O, Kazakova E, Monakhova N, Tsedilin A, Urbina F, Jones T, Suchy A, Ekins S
Journal of Medicinal Chemistry, 2023

Antiviral evaluation of dispirotripiperazines against hepatitis B virus

Jones T, Tavis JE, Li Q, Riabova O, Monakhova N, Bradley DP, Lane TR, Makarov V, Ekins S
Journal of Medicinal Chemistry, 2023

Efficacy of an isoxazole-3-carboxamide analog of pleconaril in mouse models of Enterovirus-D68 and Coxsackie B5

Lane TR, Fu J, Sherry B, Tarbet B, Hurst BL, Riabova O, Kazakova E, Egorova A, Clarke P, Leser JS, Frost J, Rudy M, Tyler KL, Klose T, Volobueva AS, Belyaevskaya SV, Zarubaev VV, Kuhn RJ, Makarov V, Ekins S
Antiviral Research, 2023

1‑Sulfonyl-3-amino‑1H‑1,2,4-triazoles as yellow fever virus inhibitors: synthesis and structure-activity relationship

Kazakova E, Lane TR, Jones J, Puhl AC, Riabova O, Makarov V, Ekins S
ACS Omega, 2023

Synthesis and evaluation of 9-aminoacridines with SARS-CoV-2 antiviral activity

Jones T, Monakhova N, Guivel-Benhassine F, Lepioshkin L, Bruel T, Lane TR, Schwartz O, Puhl AC, Makarov V, Ekins S
ACS Omega, 2023

Pyrrolo[2,3-e]indazole as a novel chemotype for both influenza A virus and pneumococcal neuraminidase inhibitors

Egorova A, Richter M, Khrenova M, Dietrich E, Tsedilin A, Kazakova E, Lepioshkin A, Jahn B, Chernyshev V, Schmidtke M, Makarov V
RSC Advances, 2023

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Новости лаборатории

МЕНЮ

КАК НАС НАЙТИ

Адрес:

Ленинский проспект 33-2, 119071 Москва

Телефон:

7-495-660-34-30 (195)

Почта:

makarov@inbi.ras.ru

Иллюстрация на обложке: Daniel Soñé, загружено с flickr.com/photos/64860478@N05/46159341865/in/album-72157705202604861/ по лицензии Public Domain Work
Иконки взяты с сайта flaticon.com

Расширяя горизонтымедицинской химиидля здоровья людей